Galderma, a leader in cosmetic fillers has announced Refyne and Defyne as the first flexible and natural appearing dermal fillers which move with each contour and movement of your face. These products are designed to help smooth out smile and laugh lines while maintaining a natural look, thereby creating a beautiful natural filler effect without any visible signs of having an treatments when you smile and show expression. We are excited to offer these next generation products, while applying the expertise we’ve accumulated through years of using Restylane. Say goodbye to stiff looking cheeks and laugh lines!

Recent Restylane winners of the coveted NEWBEAUTY Best-of Awards: 2019 – “Best Filler For Laugh Lines” – Restylane Refyne 2018 – “Best Way To Banish Laugh Lines” – Restylane Refyne and Defyne

What’s the difference?

Refyne is best for mild to moderate lines or volume loss in the lower face; particularly around the mouth and is showing incredible promise for hallows under the eyes.

Defyne is approved for moderate to deep line, volume loss and facial contouring.

Natural Results That Refyne Your Laugh Lines

A next-generation hyaluronic acid dermal filler designed to help support your skin while keeping you looking like you. New Restylane® Refyne is designed to help soften laugh lines (nasolabial folds and marionette lines). This can help you restore a more natural look to your face while maintaining your facial expressions.

The unique cross-linking of the gel in Restylane Refyne is also designed to help support your natural expression—for results that help maintain natural movement when you’re smiling, frowning and even puckering up.

Defyne Your Expression

Invest in yourself with real-life results that help maintain natural movement to help keep you looking like you. New Restylane® Defyne helps smooth out deep laugh lines (nasolabial folds and marionette lines). Using innovative cross-linking technology, Restylane Defyne is a hyaluronic acid dermal filler that is able to help restore a more youthful, natural-looking appearance, while helping you maintain your natural expressions.

In a clinical study, subjects were evaluated based on perception of the naturalness of facial expressions in motion after 1 month of Restylane Defyne and Restylane Refyne optimal treatment.

• 97% of treated subjects were satisfied with their treatment results • 97% of treated subjects would do the treatment again • 95% of treated subjects would recommend the products to a friend

Galderma At-A-Glance Brochure

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